Claude Opus 4.1 vs Mixtral 8x22B Instruct
Claude Opus 4.1 leads Mixtral 8x22B Instruct on the Artificial Analysis Intelligence Index, 22.8 to 5.7, and Mixtral 8x22B Instruct costs 12.5x less per output token ($6.00 vs $75.00 per million). Updated October 21, 2026; 4 benchmarks have a result for both.
Claude Opus 4.1 or Mixtral 8x22B Instruct: which to pick
Neither model has a coding score yet, so the two cannot be ranked on coding.
Pick Claude Opus 4.1 for a larger context window (200K against 66K tokens).
- Shared results
- 4
- Claude Opus 4.1 only
- 69
- Mixtral 8x22B Instruct only
- 4
- Like-for-like categories
- 3 of 9
Only benchmarks that tested both models count toward a pick; a result only one model has is shown but not compared.
Which one for your work
Each card is decided by one number both models carry. Where only one has it, the card says so and makes no call.
Coding
Vibe Coding Index, six public coding benchmarks
No call
Neither has a coding score yet.
One side not measured
Intelligence
AA Intelligence Index
Claude Opus 4.1
Claude Opus 4.1 leads, 22.8 against 5.7.
Same board, both measured
Reasoning
GPQA Diamond
No call
Only Claude Opus 4.1 has a GPQA Diamond result, 76.3%.
Directional only
Math
AIME
No call
Only Claude Opus 4.1 has a AIME result, 78.2%.
Directional only
Knowledge
MMLU Pro
No call
Only Claude Opus 4.1 has a MMLU Pro result, 87.9%.
Directional only
Web design
Design Arena: websites
No call
Only Claude Opus 4.1 has a Design Arena: websites result, 1177.
Directional only
Long documents
Listed context window
Claude Opus 4.1
Claude Opus 4.1 takes 200K tokens against 66K.
Listed by OpenRouter
Everyday cost
1K input + 500 output tokens
Mixtral 8x22B Instruct
Claude Opus 4.1 $0.052, Mixtral 8x22B Instruct $0.0050 per turn.
List prices
At a glance
- Coding index
- Claude Opus 4.1 not benchmarked, Mixtral 8x22B Instruct not benchmarked.
- Widest category
- General, 24.9 points apart on average over 1 shared benchmark.
- Widest single gap
- Epoch Capabilities Index: Claude Opus 4.1 144.1 against Mixtral 8x22B Instruct 122.0, 27.5 points apart on a 0 to 100 scale.
- Output price
- Claude Opus 4.1 $75.00 against Mixtral 8x22B Instruct $6.00 per million output tokens, 12.5x apart.
- Context window
- Claude Opus 4.1 takes 200K tokens, Mixtral 8x22B Instruct 66K.
Benchmark by benchmark
First the score: boards each model leads, per category, where both have a result. Then every board, a category to a fold; bars are each result on a 0 to 100 scale, so compare the two in a row, not one row with another.
| Category | Claude Opus 4.1 | Bars | Mixtral 8x22B Instruct | Ties |
|---|---|---|---|---|
| Coding | 1 | 0 | ||
| Intelligence | 2 | 0 | ||
| General | 1 | 0 | ||
| All shared boards | 4 | 0 |
CodingLike-for-likeSix of these boards feed the Vibe Coding Index10
| Benchmark | Claude Opus 4.1 | Mixtral 8x22B Instruct | Leader |
|---|---|---|---|
| LMArena WebDev | 1390 | Not measured | Only Claude Opus 4.1 measured |
| LiveCodeBench (Vals AI) | 66.5% | Not measured | Only Claude Opus 4.1 measured |
| LiveCodeBench (Artificial Analysis run) | Not measured | 14.8% | Only Mixtral 8x22B Instruct measured |
| Terminal-Bench | 38.0% | Not measured | Only Claude Opus 4.1 measured |
| WeirdML | 45.9% | Not measured | Only Claude Opus 4.1 measured |
| Cybench | 42.0% | Not measured | Only Claude Opus 4.1 measured |
| LMArena Text: coding | 1479 | Not measured | Only Claude Opus 4.1 measured |
| LMArena Text: software and IT | 1456 | Not measured | Only Claude Opus 4.1 measured |
| LMArena WebDev: HTML | 1399 | Not measured | Only Claude Opus 4.1 measured |
| SciCode | 4.6% | 0.0% | Claude Opus 4.1 |
| Neither model has a result on the other 29 boards here | |||
IntelligenceLike-for-likePublic boards, shown as published, kept out of the index20
| Benchmark | Claude Opus 4.1 | Mixtral 8x22B Instruct | Leader |
|---|---|---|---|
| AA Intelligence Index | 22.8 | 5.7 | Claude Opus 4.1 |
| Epoch Capabilities Index | 144.1 | 122.0 | Claude Opus 4.1 |
Agentic workDirectional onlyPublic boards, shown as published, kept out of the index3 boards, none shared
| Benchmark | Claude Opus 4.1 | Mixtral 8x22B Instruct | Leader |
|---|---|---|---|
| METR time horizons | 66.8% | Not measured | Only Claude Opus 4.1 measured |
| GDPval | 43.6% | Not measured | Only Claude Opus 4.1 measured |
| DeepResearch Bench | 48.3% | Not measured | Only Claude Opus 4.1 measured |
| Neither model has a result on the other 38 boards here | |||
ReasoningDirectional onlyPublic boards, shown as published, kept out of the index12 boards, none shared
| Benchmark | Claude Opus 4.1 | Mixtral 8x22B Instruct | Leader |
|---|---|---|---|
| GPQA Diamond | 76.3% | Not measured | Only Claude Opus 4.1 measured |
| MMMU Pro (Vals AI) | 77.5% | Not measured | Only Claude Opus 4.1 measured |
| GPQA Diamond (Artificial Analysis run) | Not measured | 33.2% | Only Mixtral 8x22B Instruct measured |
| Humanity's Last Exam (Artificial Analysis run) | Not measured | 4.0% | Only Mixtral 8x22B Instruct measured |
| GPQA Diamond (Epoch AI run) | 77.3% | Not measured | Only Claude Opus 4.1 measured |
| SimpleBench | 60.0% | Not measured | Only Claude Opus 4.1 measured |
| Mystery game puzzles | 21.0% | Not measured | Only Claude Opus 4.1 measured |
| EBR-bench | 7.9% | Not measured | Only Claude Opus 4.1 measured |
| VPCT | 35.0% | Not measured | Only Claude Opus 4.1 measured |
| LMArena Text: hard prompts | 1442 | Not measured | Only Claude Opus 4.1 measured |
| LMArena Text: expert | 1438 | Not measured | Only Claude Opus 4.1 measured |
| LMArena Text: hard prompts in English | 1451 | Not measured | Only Claude Opus 4.1 measured |
| Neither model has a result on the other 10 boards here | |||
MathDirectional onlyPublic boards, shown as published, kept out of the index8 boards, none shared
| Benchmark | Claude Opus 4.1 | Mixtral 8x22B Instruct | Leader |
|---|---|---|---|
| AIME | 78.2% | Not measured | Only Claude Opus 4.1 measured |
| MATH 500 (Vals AI) | 95.4% | Not measured | Only Claude Opus 4.1 measured |
| MGSM (Vals AI) | 94.4% | Not measured | Only Claude Opus 4.1 measured |
| OTIS Mock AIME | 68.9% | Not measured | Only Claude Opus 4.1 measured |
| FrontierMath, tiers 1 to 3 | 12.6% | Not measured | Only Claude Opus 4.1 measured |
| FrontierMath, tier 4 | 2.4% | Not measured | Only Claude Opus 4.1 measured |
| LMArena Text: math | 1431 | Not measured | Only Claude Opus 4.1 measured |
| LMArena Text: mathematical work | 1434 | Not measured | Only Claude Opus 4.1 measured |
| Neither model has a result on the other 5 boards here | |||
KnowledgeDirectional onlyPublic boards, shown as published, kept out of the index12 boards, none shared
| Benchmark | Claude Opus 4.1 | Mixtral 8x22B Instruct | Leader |
|---|---|---|---|
| MMLU Pro | 87.9% | Not measured | Only Claude Opus 4.1 measured |
| LegalBench (Vals AI) | 83.5% | Not measured | Only Claude Opus 4.1 measured |
| TaxEval (Vals AI) | 73.7% | Not measured | Only Claude Opus 4.1 measured |
| MortgageTax (Vals AI) | 61.1% | Not measured | Only Claude Opus 4.1 measured |
| MedQA (Vals AI) | 93.6% | Not measured | Only Claude Opus 4.1 measured |
| MedCode (Vals AI) | 47.2% | Not measured | Only Claude Opus 4.1 measured |
| MMLU Pro (Artificial Analysis run) | Not measured | 53.7% | Only Mixtral 8x22B Instruct measured |
| LMArena Text: science | 1422 | Not measured | Only Claude Opus 4.1 measured |
| LMArena Text: medicine and healthcare | 1416 | Not measured | Only Claude Opus 4.1 measured |
| LMArena Text: legal and government | 1421 | Not measured | Only Claude Opus 4.1 measured |
| LMArena Text: business and finance | 1406 | Not measured | Only Claude Opus 4.1 measured |
| FACTS Benchmark Suite | 40.4% | Not measured | Only Claude Opus 4.1 measured |
| Neither model has a result on the other 6 boards here | |||
Web designDirectional onlyPublic boards, shown as published, kept out of the index8 boards, none shared
| Benchmark | Claude Opus 4.1 | Mixtral 8x22B Instruct | Leader |
|---|---|---|---|
| Design Arena: websites | 1177 | Not measured | Only Claude Opus 4.1 measured |
| Design Arena: UI components | 1165 | Not measured | Only Claude Opus 4.1 measured |
| Design Arena: game dev | 1171 | Not measured | Only Claude Opus 4.1 measured |
| Design Arena: data viz | 1166 | Not measured | Only Claude Opus 4.1 measured |
| Design Arena: 3D | 1153 | Not measured | Only Claude Opus 4.1 measured |
| Design Arena: all code categories | 1171 | Not measured | Only Claude Opus 4.1 measured |
| Design Arena: SVG | 1152 | Not measured | Only Claude Opus 4.1 measured |
| Design Arena: ASCII art | 1167 | Not measured | Only Claude Opus 4.1 measured |
| Neither model has a result on the other 1 board here | |||
GeneralLike-for-likePublic boards, shown as published, kept out of the index10
| Benchmark | Claude Opus 4.1 | Mixtral 8x22B Instruct | Leader |
|---|---|---|---|
| SAGE (Vals AI) | 31.4% | Not measured | Only Claude Opus 4.1 measured |
| MedScribe (Vals AI) | 73.9% | Not measured | Only Claude Opus 4.1 measured |
| DTBench | 80.0% | 55.1% | Claude Opus 4.1 |
| LMCA | 37.1% | Not measured | Only Claude Opus 4.1 measured |
| Creative writing (Lech Mazur) | 84.7% | Not measured | Only Claude Opus 4.1 measured |
| LMArena Text | 1419 | Not measured | Only Claude Opus 4.1 measured |
| LMArena Text: instruction following | 1435 | Not measured | Only Claude Opus 4.1 measured |
| LMArena Text: creative writing | 1412 | Not measured | Only Claude Opus 4.1 measured |
| LMArena Text: English | 1433 | Not measured | Only Claude Opus 4.1 measured |
| LMArena Text: non-English | 1405 | Not measured | Only Claude Opus 4.1 measured |
| LMArena Text: Chinese | 1427 | Not measured | Only Claude Opus 4.1 measured |
| LMArena Text: German | 1413 | Not measured | Only Claude Opus 4.1 measured |
| LMArena Text: Japanese | 1377 | Not measured | Only Claude Opus 4.1 measured |
| LMArena Text: Korean | 1381 | Not measured | Only Claude Opus 4.1 measured |
| LMArena Text: French | 1433 | Not measured | Only Claude Opus 4.1 measured |
| LMArena Text: Spanish | 1448 | Not measured | Only Claude Opus 4.1 measured |
| LMArena Text: Russian | 1422 | Not measured | Only Claude Opus 4.1 measured |
| LMArena Text: Polish | 1413 | Not measured | Only Claude Opus 4.1 measured |
| LMArena Text: multi-turn | 1444 | Not measured | Only Claude Opus 4.1 measured |
| LMArena Text: longer queries | 1455 | Not measured | Only Claude Opus 4.1 measured |
| LMArena Text: writing and language | 1418 | Not measured | Only Claude Opus 4.1 measured |
| LMArena Text: entertainment and media | 1398 | Not measured | Only Claude Opus 4.1 measured |
| Neither model has a result on the other 24 boards here | |||
Image generationNot comparablePublic boards, shown as published, kept out of the index0 boards, none shared
| Benchmark | Claude Opus 4.1 | Mixtral 8x22B Instruct | Leader |
|---|---|---|---|
| Neither model has a result on 5 boards here | |||
What each workload costs
Three fixed token mixes at each model's listed price, so per-token rates become a bill.
Chat turn
1K input + 500 output tokens
Mixtral 8x22B Instruct costs less
Repository review
50K input + 3K output tokens
Mixtral 8x22B Instruct costs less
Agent loop
200K input + 10K output tokens
Mixtral 8x22B Instruct costs less
Listed OpenRouter rates, without cache or batch discounts. A workload that does not fit a model's context window would need splitting.
Specification differences
The leading value in a row is marked; a row with a missing value names no leader. Our two rows are marked in red.
| Specification | Anthropic Claude Opus 4.1 | Mistral Mixtral 8x22B Instruct |
|---|---|---|
| Maker | Anthropic | Mistral AI |
| Weights | No public weights listed | Open weights |
| Released | August 5, 2025 | April 17, 2024 |
| Context window | 200K | 66K |
| Input $/Mtok | $15.00 | $2.00 |
| Output $/Mtok | $75.00 | $6.00 |
| Coding index | Not benchmarked | Not benchmarked |
| Independent measurements behind it | 1 | 0 |
| Cost per solved task | Not computable | Not computable |
| Source | OpenRouter listing | OpenRouter listing |
Questions
Is Claude Opus 4.1 better than Mixtral 8x22B Instruct for coding?
Neither model has a coding score yet, so the two cannot be ranked on coding. Pick Claude Opus 4.1 for a larger context window (200K against 66K tokens).
Which is cheaper, Claude Opus 4.1 or Mixtral 8x22B Instruct?
Claude Opus 4.1 costs $15.00 per million input tokens and $75.00 per million output tokens; Mixtral 8x22B Instruct costs $2.00 and $6.00. Cost per solved task is known for neither of them.
Which has the bigger context window, Claude Opus 4.1 or Mixtral 8x22B Instruct?
Claude Opus 4.1, with 200K tokens against 66K.
How many benchmarks is the Claude Opus 4.1 vs Mixtral 8x22B Instruct comparison based on?
4 benchmarks have a result for both models as of October 21, 2026. Claude Opus 4.1's coding index rests on 1 independent benchmark and Mixtral 8x22B Instruct's on 0. Where only one model has a result, the page says so instead of naming a winner.