Mixtral 8x22B Instruct vs Hermes 4 405B
Hermes 4 405B leads Mixtral 8x22B Instruct on the Artificial Analysis Intelligence Index, 7.5 to 5.7, and Hermes 4 405B costs 2.0x less per output token ($3.00 vs $6.00 per million). Updated October 22, 2026; 1 benchmarks have a result for both.
Mixtral 8x22B Instruct or Hermes 4 405B: which to pick
Neither model has a coding score yet, so the two cannot be ranked on coding.
Pick Mixtral 8x22B Instruct for work measured by AA Intelligence Index, where it leads.
- Shared results
- 1
- Mixtral 8x22B Instruct only
- 7
- Hermes 4 405B only
- 1
- Like-for-like categories
- 1 of 9
Only benchmarks that tested both models count toward a pick; a result only one model has is shown but not compared.
Which one for your work
Each card is decided by one number both models carry. Where only one has it, the card says so and makes no call.
Coding
Vibe Coding Index, six public coding benchmarks
No call
Neither has a coding score yet.
One side not measured
Intelligence
AA Intelligence Index
Hermes 4 405B
Hermes 4 405B leads, 7.5 against 5.7.
Same board, both measured
Long documents
Listed context window
Hermes 4 405B
Hermes 4 405B takes 131K tokens against 66K.
Listed by OpenRouter
Everyday cost
1K input + 500 output tokens
Hermes 4 405B
Mixtral 8x22B Instruct $0.0050, Hermes 4 405B $0.0025 per turn.
List prices
At a glance
- Coding index
- Mixtral 8x22B Instruct not benchmarked, Hermes 4 405B not benchmarked.
- Widest category
- Intelligence, 1.8 points apart on average over 1 shared benchmark.
- Widest single gap
- AA Intelligence Index: Mixtral 8x22B Instruct 5.7 against Hermes 4 405B 7.5, 1.8 points apart on a 0 to 100 scale.
- Output price
- Mixtral 8x22B Instruct $6.00 against Hermes 4 405B $3.00 per million output tokens, 2.0x apart.
- Context window
- Mixtral 8x22B Instruct takes 66K tokens, Hermes 4 405B 131K.
Benchmark by benchmark
First the score: boards each model leads, per category, where both have a result. Then every board, a category to a fold; bars are each result on a 0 to 100 scale, so compare the two in a row, not one row with another.
| Category | Mixtral 8x22B Instruct | Bars | Hermes 4 405B | Ties |
|---|---|---|---|---|
| Intelligence | 0 | 1 | ||
| All shared boards | 0 | 1 |
CodingDirectional onlySix of these boards feed the Vibe Coding Index2 boards, none shared
| Benchmark | Mixtral 8x22B Instruct | Hermes 4 405B | Leader |
|---|---|---|---|
| LiveCodeBench (Artificial Analysis run) | 14.8% | Not measured | Only Mixtral 8x22B Instruct measured |
| SciCode | 0.0% | Not measured | Only Mixtral 8x22B Instruct measured |
| Neither model has a result on the other 37 boards here | |||
IntelligenceLike-for-likePublic boards, shown as published, kept out of the index01
| Benchmark | Mixtral 8x22B Instruct | Hermes 4 405B | Leader |
|---|---|---|---|
| AA Intelligence Index | 5.7 | 7.5 | Hermes 4 405B |
| Epoch Capabilities Index | 122.0 | Not measured | Only Mixtral 8x22B Instruct measured |
Agentic workNot comparablePublic boards, shown as published, kept out of the index0 boards, none shared
| Benchmark | Mixtral 8x22B Instruct | Hermes 4 405B | Leader |
|---|---|---|---|
| Neither model has a result on 41 boards here | |||
ReasoningDirectional onlyPublic boards, shown as published, kept out of the index3 boards, none shared
| Benchmark | Mixtral 8x22B Instruct | Hermes 4 405B | Leader |
|---|---|---|---|
| GPQA Diamond (Artificial Analysis run) | 33.2% | Not measured | Only Mixtral 8x22B Instruct measured |
| Humanity's Last Exam (Artificial Analysis run) | 4.0% | Not measured | Only Mixtral 8x22B Instruct measured |
| Kagi LLM Benchmark | Not measured | 55.8% | Only Hermes 4 405B measured |
| Neither model has a result on the other 19 boards here | |||
MathNot comparablePublic boards, shown as published, kept out of the index0 boards, none shared
| Benchmark | Mixtral 8x22B Instruct | Hermes 4 405B | Leader |
|---|---|---|---|
| Neither model has a result on 13 boards here | |||
KnowledgeDirectional onlyPublic boards, shown as published, kept out of the index1 board, none shared
| Benchmark | Mixtral 8x22B Instruct | Hermes 4 405B | Leader |
|---|---|---|---|
| MMLU Pro (Artificial Analysis run) | 53.7% | Not measured | Only Mixtral 8x22B Instruct measured |
| Neither model has a result on the other 17 boards here | |||
Web designNot comparablePublic boards, shown as published, kept out of the index0 boards, none shared
| Benchmark | Mixtral 8x22B Instruct | Hermes 4 405B | Leader |
|---|---|---|---|
| Neither model has a result on 9 boards here | |||
GeneralDirectional onlyPublic boards, shown as published, kept out of the index1 board, none shared
| Benchmark | Mixtral 8x22B Instruct | Hermes 4 405B | Leader |
|---|---|---|---|
| DTBench | 55.1% | Not measured | Only Mixtral 8x22B Instruct measured |
| Neither model has a result on the other 45 boards here | |||
Image generationNot comparablePublic boards, shown as published, kept out of the index0 boards, none shared
| Benchmark | Mixtral 8x22B Instruct | Hermes 4 405B | Leader |
|---|---|---|---|
| Neither model has a result on 5 boards here | |||
What each workload costs
Three fixed token mixes at each model's listed price, so per-token rates become a bill.
Chat turn
1K input + 500 output tokens
Hermes 4 405B costs less
Repository review
50K input + 3K output tokens
Hermes 4 405B costs less
Agent loop
200K input + 10K output tokens
Hermes 4 405B costs less
Listed OpenRouter rates, without cache or batch discounts. A workload that does not fit a model's context window would need splitting.
Specification differences
The leading value in a row is marked; a row with a missing value names no leader. Our two rows are marked in red.
| Specification | Mistral Mixtral 8x22B Instruct | Nous Hermes 4 405B |
|---|---|---|
| Maker | Mistral AI | Nous Research |
| Weights | Open weights | Open weights |
| Released | April 17, 2024 | August 26, 2025 |
| Context window | 66K | 131K |
| Input $/Mtok | $2.00 | $1.00 |
| Output $/Mtok | $6.00 | $3.00 |
| Coding index | Not benchmarked | Not benchmarked |
| Independent measurements behind it | 0 | 0 |
| Cost per solved task | Not computable | Not computable |
| Source | OpenRouter listing | OpenRouter listing |
Questions
Is Mixtral 8x22B Instruct better than Hermes 4 405B for coding?
Neither model has a coding score yet, so the two cannot be ranked on coding. Pick Mixtral 8x22B Instruct for work measured by AA Intelligence Index, where it leads.
Which is cheaper, Mixtral 8x22B Instruct or Hermes 4 405B?
Mixtral 8x22B Instruct costs $2.00 per million input tokens and $6.00 per million output tokens; Hermes 4 405B costs $1.00 and $3.00. Cost per solved task is known for neither of them.
Which has the bigger context window, Mixtral 8x22B Instruct or Hermes 4 405B?
Hermes 4 405B, with 131K tokens against 66K.
How many benchmarks is the Mixtral 8x22B Instruct vs Hermes 4 405B comparison based on?
1 benchmarks have a result for both models as of October 22, 2026. Mixtral 8x22B Instruct's coding index rests on 0 independent benchmarks and Hermes 4 405B's on 0. Where only one model has a result, the page says so instead of naming a winner.